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    Genestra Cal Mag Vanilla Liquid+ 450ml

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    $45.00
    SKU 34086415
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    Organic calcium and magnesium citrate minerals plus vitamins D and K
    • 500 mg of calcium and 200 mg of magnesium per tablespoon dose
    • With 1000 IU of vitamin D, 40 mcg of vitamin K1 and 60 mcg of vitamin K2
    • Helps in the maintenance of bones, teeth, and proper muscle function
    • Helps to prevent vitamin D deficiency
    • Calcium intake, when combined with sufficient vitamin D, a healthy diet and regular exercise, may reduce the risk of developing osteoporosis
    • Great-tasting natural vanilla flavour

    Cal Mag Vanilla Liquid + helps to maintain bone health and muscle function using a combination of organic calcium and magnesium citrate minerals, plus vitamins D and K. Osteoporosis is the primary cause of bone fractures in postmenopausal women 50 years and older, with an estimated 80% of all fractures in this group being osteoporosis related.1 Regular physical activity helps to maintain bone mass during aging, as bone metabolism is stimulated by the mechanical stress generated from impacts.2-5 However, supplementation with calcium and vitamin D may support bone formation even when incorporated into a low-impact physical exercise program. In a randomized clinical trial, 64 healthy postmenopausal women received 500 mg of calcium and 1000 IU of vitamin D daily while undergoing 6 months of low-impact aquatic exercise. At the end of the study period, there was a 15.8% increase in bone formation biomarker P1NP (precollagen type 1 amino-terminal propeptide) compared to baseline measurements.6 P1NP has been identified as a clinically relevant osteoporosis risk biomarker by the Bone Marker Standards Working Group.7 Vitamin K helps to maintain bone health, partly via the activation of gamma-carboxyglutamic acid (GLA) proteins involved in skeletal mineralization, such as matrix Gla protein (MGP) and osteocalcin.8,9 Low vitamin K status may impair the function of Gla proteins involved in regulation of bone mineralization.10

     

    REFERENCES
    1. Bessette L, Ste-Marie LG, Jean S, Davison KS, Beaulieu M, Baranci M, Bessant J, Brown JP. Osteoporos Int. 2008; 19: 79-86
    2. Yamazaki S, Ichimura S, Iwamoto J, Takeda T, Toyama Y. J Bone Miner Metab. 2004; 22: 500-508
    3. Chien MY, Wu YT, Hsu AT, Yang RS, Lai JS. Calcif Tissue Int. 2000; 67: 443-448
    4. Bemben DA, Bemben MG. Osteoporos Int. 2011; 22: 179-186
    5. Vainionpää A, Korpelainen R, Leppäluoto J, Jämsä T. Osteoporos Int. 2005; 16: 191-198
    6. Moreira LDF, Fronza FCAO, dos Santos RN, Zach PL, Kunii IS, Hayashi LF et al.  J Bone Miner Metab. 2014; 32: 411-419
    7. Wheater G, Elshahaly M, Tuck SP, Datta H, Van Laar JM. Journal of Translational Medicine. 2013, 11: 201
    8. Price P. Connect Tissue Res. 1989; 21:51-57
    9. Loeser R, Varnum B, Carlson C, et al. Arthritis Rheum. 1997; 40:1455-1465
    10. Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE et al. Am J Med. 2013; 126(3): 243-248